US 12,082,574 B2
Biomaterial preservation composition having a microbubble with oxygen gas in liquid, method for preserving biomaterial in the biomaterial preservation composition, method for preserving biomaterial in the biomaterial preservation composition, method for producing biomaterial using the biomaterial preservation composition, transplantation material using the biomaterial preservation composition and method of transplantation using the biomaterial preservation composition
Naoyuki Hatayama, Nagakute (JP); Munekazu Naito, Nagakute (JP); Shuichi Hirai, Nagakute (JP); and Shigeki Sakaue, Hyogo (JP)
Assigned to AICHI MEDICAL UNIVERSITY, Aichi (JP); and SUMITOMO SEIKA CHEMICALS CO., LTD., Hyogo (JP)
Appl. No. 17/044,805
Filed by Aichi Medical University, Aichi (JP); and Sumitomo Seika Chemicals Co., Ltd., Hyogo (JP)
PCT Filed May 31, 2019, PCT No. PCT/JP2019/021855
§ 371(c)(1), (2) Date Oct. 1, 2020,
PCT Pub. No. WO2019/230973, PCT Pub. Date Dec. 5, 2019.
Claims priority of application No. 2018-105405 (JP), filed on May 31, 2018; and application No. 2018-226902 (JP), filed on Dec. 3, 2018.
Prior Publication US 2021/0195887 A1, Jul. 1, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A01N 1/02 (2006.01)
CPC A01N 1/021 (2013.01) 7 Claims
 
1. A biomaterial preservation composition comprising a microbubble in a liquid, wherein
the micro bubble comprises (i) oxygen (O2) gas, and (ii) at least one of carbon monoxide (CO) gas and hydrogen sulfide (H2S) gas,
wherein the gas of the micro bubble directly contacts with the liquid;
wherein the micro bubble density is 6.84×105 to 5×1012 bubbles/ml;
wherein the mean diameter of the bubbles is less than 1 μm; and
wherein the biomaterial comprises at least a part of a living body or an organ.