US 11,753,368 B2
Treatment of sleep-wake disorders
Abdallah Ahnaou, Berchem (BE); Wilhelmus H. I. M. Drinkenburg, Molenschot (NL); Joseph Palumbo, Saint Davids, PA (US); and Jonathan Sporn, Princeton, NJ (US)
Assigned to SK Biopharmaceuticals Co., Ltd., Seongnam-si (KR)
Filed by SK Biopharmaceuticals Co., Ltd., Seongnam-si (KR)
Filed on Sep. 28, 2020, as Appl. No. 17/34,564.
Application 17/034,564 is a continuation of application No. 16/420,834, filed on May 23, 2019, abandoned.
Application 16/420,834 is a continuation of application No. 15/433,660, filed on Feb. 15, 2017, granted, now 10,351,517, issued on Jul. 16, 2019.
Application 15/433,660 is a continuation of application No. 14/452,816, filed on Aug. 6, 2014, granted, now 9,604,917, issued on Mar. 28, 2017.
Application 14/452,816 is a continuation of application No. 13/747,508, filed on Jan. 23, 2013, granted, now 8,877,806, issued on Nov. 4, 2014.
Application 13/747,508 is a continuation of application No. 11/921,995, granted, now 8,440,715, issued on May 14, 2013, previously published as PCT/US2006/022407, filed on Jun. 7, 2006.
Claims priority of provisional application 60/688,638, filed on Jun. 8, 2005.
Prior Publication US 2021/0078943 A1, Mar. 18, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 271/12 (2006.01); A61K 31/165 (2006.01); A61K 31/27 (2006.01); A61K 9/00 (2006.01)
CPC C07C 271/12 (2013.01) [A61K 9/0053 (2013.01); A61K 31/165 (2013.01); A61K 31/27 (2013.01)] 10 Claims
1. A method of treating a sleep-wake disorder in a subject, comprising administration, to a subject in need of such treatment, of a therapeutically effective amount of a compound of the Formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt or ester thereof wherein R, R1, R2 are hydrogen and x=1, and
wherein the cause of the sleep-wake disorder is chosen from the group consisting of stroke, narcolepsy, idiopathic CNS hypersomnia, sleep deficiency, sleep apnea, obstructive sleep apnea, insufficient nocturnal sleep, chronic pain, acute pain, Parkinson's disease, urinary incontinence, multiple sclerosis fatigue, Attention Deficit Hyperactivity Disorder (ADHD), Alzheimer's disorder, cardiac ischemia, misalignments of the body's circadian pacemaker with the environment, jet lag, shift work, and sedating drugs.