US 11,752,341 B2
Display signal to assess autonomic response to vagus nerve stimulation treatment
Imad Libbus, St. Paul, MN (US); Scott R. Stubbs, Maple Grove, MN (US); Scott Mazar, Woodbury, MN (US); Bruce KenKnight, Maple Grove, MN (US); and Badri Amurthur, Los Gatos, CA (US)
Assigned to LivaNova USA, Inc., Houston, TX (US)
Appl. No. 17/54,996
Filed by LivaNova USA, Inc., Houston, TX (US)
PCT Filed May 13, 2019, PCT No. PCT/US2019/031992
§ 371(c)(1), (2) Date Nov. 12, 2020,
PCT Pub. No. WO2019/222087, PCT Pub. Date Nov. 21, 2019.
Claims priority of provisional application 62/672,011, filed on May 15, 2018.
Prior Publication US 2021/0213291 A1, Jul. 15, 2021
Int. Cl. A61N 1/36 (2006.01); A61N 1/372 (2006.01)
CPC A61N 1/36114 (2013.01) [A61N 1/36139 (2013.01); A61N 1/36175 (2013.01); A61N 1/37247 (2013.01)] 20 Claims
OG exemplary drawing
1. An assessment system for vagus nerve stimulation therapy treatment for congestive heart failure in a subject, the assessment system comprising:
a first interface configured to communicate with a device that delivers a stimulation signal to a vagus nerve of the subject;
a second interface configured to capture heart electrical activity of the subject in response to the stimulation signal; and
a processor and a non-transitory computer readable memory storing instructions that, when executed by the processor, cause the assessment system to:
segregate the captured heart electrical activity into portions that correspond to at least one ON-period of the stimulation signal and at least one OFF-period of the stimulation signal based on a communication between the first interface and the device that delivers the stimulation signal; and
determine and display real-time heart rate dynamics for each of the at least one ON-period and the at least one OFF-period and display a digital ECG signal in real-time in response to the stimulation signal.