US 11,752,156 B2
Compositions and methods for treating hyperproliferative skin disorders
Johnson Yiu-Nam Lau, Houston, TX (US); Alissa Rae Verone-Boyle, Kenmore, NY (US); Chun-Ho Wong, Shatin (HK); Yahao Bu, Williamsville, NY (US); Murray John Cutler, Fort Erie (CA); Krista Elizabeth Belko, Clarence Center, NY (US); and Min-Fun Rudolf Kwan, Summit, NJ (US)
Assigned to Athenex HK Innovative Limited, Sha Tin (HK)
Appl. No. 16/978,037
Filed by Athenex HK Innovative Limited, Hong Kong (HK)
PCT Filed Mar. 6, 2019, PCT No. PCT/US2019/021037
§ 371(c)(1), (2) Date Sep. 3, 2020,
PCT Pub. No. WO2019/173533, PCT Pub. Date Sep. 12, 2019.
Claims priority of provisional application 62/639,742, filed on Mar. 7, 2018.
Prior Publication US 2021/0038608 A1, Feb. 11, 2021
Int. Cl. A61K 31/5377 (2006.01); A61K 31/593 (2006.01); A61P 17/06 (2006.01); A61P 17/00 (2006.01); A61N 5/06 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/5377 (2013.01) [A61K 31/593 (2013.01); A61N 5/062 (2013.01); A61N 5/0616 (2013.01); A61K 9/0014 (2013.01); A61K 45/06 (2013.01); A61N 2005/0661 (2013.01)] 8 Claims
 
1. A method of treating actinic keratosis in a subject in need thereof, the method comprising:
topically applying, to an area of the subject's skin affected by actinic keratosis, an effective amount of a composition comprising calcipotriol and KX01, which has the following structure:

OG Complex Work Unit Chemistry
and
wherein the calcipotriol and the KX01 are present in synergistic concentrations that are therapeutically effective.