US 12,412,739 B2
Charge reduced mass spectrometry for sequencing of oligonucleotide therapeutics
Takashi Baba, Richmond Hill (CA); and Kaoru Karasawa, Tokyo (JP)
Assigned to DH TECHNOLOGIES DEVELOPMENT PTE. LTD., Singapore (SG)
Appl. No. 18/016,162
Filed by DH Technologies Development Pte. Ltd., Singapore (SG)
PCT Filed Jul. 12, 2021, PCT No. PCT/IB2021/056258
§ 371(c)(1), (2) Date Jan. 13, 2023,
PCT Pub. No. WO2022/013716, PCT Pub. Date Jan. 20, 2022.
Claims priority of provisional application 63/051,686, filed on Jul. 14, 2020.
Prior Publication US 2023/0343570 A1, Oct. 26, 2023
Int. Cl. H01J 49/00 (2006.01); H01J 49/06 (2006.01)
CPC H01J 49/0045 (2013.01) [H01J 49/062 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of performing mass spectrometry, comprising:
ionizing a plurality of oligonucleotides to generate a plurality of negatively charged oligonucleotide ions, and
interacting a plurality of positively charged reagent ions with said negatively charged oligonucleotide ions to reduce the negative charge states of said negatively charged oligonucleotide ions.