	US 12,411,142 B2
	Method for measuring the trimethylamine n-oxide production capacity in an individual
Wei-Kai Wu, Taipei (TW); Ming-Shiang Wu, Taipei (TW); and Lee-Yan Sheen, Taipei (TW)
Assigned to NATIONAL TAIWAN UNIVERSITY, Taipei (TW)
Appl. No. 17/268,337
Filed by NATIONAL TAIWAN UNIVERSITY, Taipei (TW)
PCT Filed Aug. 13, 2019, PCT No. PCT/CN2019/100312 § 371(c)(1), (2) Date Feb. 12, 2021, PCT Pub. No. WO2020/034932, PCT Pub. Date Feb. 20, 2020.
Claims priority of provisional application 62/717,975, filed on Aug. 13, 2018.
Prior Publication US 2021/0164999 A1, Jun. 3, 2021
Int. Cl. G01N 33/483 (2006.01); A61K 31/205 (2006.01); G01N 33/68 (2006.01)

CPC G01N 33/6893 (2013.01) [A61K 31/205 (2013.01); G01N 2800/042 (2013.01); G01N 2800/044 (2013.01); G01N 2800/323 (2013.01); G01N 2800/50 (2013.01); G01N 2800/52 (2013.01)]

7 Claims

1. A method for measuring the trimethylamine N-oxide (TMAO) production capacity in a subject, the method comprising the following steps:

(a) making the subject ingest a specific dosage of carnitine; and

(b) obtaining a body fluid sample of the subject at 24 hours and 48 hours after the subject ingests the carnitine and detecting the TMAO content in the body fluid sample,

wherein the body fluid sample of the subject is urine.