	US 12,410,457 B2
	Use of rosmarinic acid in cell bioproduction
Jun Tian, Westford, MA (US); Jianlin Xu, Littleton, MA (US); and Qin He, Littleton, MA (US)
Assigned to Bristol-Myers Squibb Company, Princeton, NJ (US)
Filed by BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US)
Filed on Jul. 1, 2021, as Appl. No. 17/365,673.
Application 17/365,673 is a division of application No. 16/782,195, filed on Feb. 5, 2020, granted, now 11,078,512.
Application 16/782,195 is a continuation of application No. 15/549,760, granted, now 10,590,457, issued on Mar. 17, 2020, previously published as PCT/US2016/017432, filed on Feb. 11, 2016.
Claims priority of provisional application 62/114,635, filed on Feb. 11, 2015.
Prior Publication US 2023/0002800 A1, Jan. 5, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C12P 21/02 (2006.01); C12N 5/00 (2006.01); C12Q 1/04 (2006.01)

CPC C12P 21/02 (2013.01) [C12N 5/0018 (2013.01); C12Q 1/04 (2013.01)]

10 Claims

1. A cell culture process for the production of protein, comprising culturing Chinese Hamster Ovary (CHO) cells in a basal media which produce a protein of interest in cell culture under conditions that allow for protein production, wherein rosmarinic acid is added to the basal media.