US 12,410,261 B2
Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
Jong Seo Lee, Yongin-si (KR); Kyu Tae Kim, Yongin-si (KR); Young Ha Lee, Yongin-si (KR); In Sik Hwang, Yongin-si (KR); Bong Kook Ko, Yongin-si (KR); Eunji Choi, Yongin-si (KR); You-Sun Kim, Yongin-si (KR); Jeongmin Kim, Yongin-si (KR); Miyoung Jung, Yongin-si (KR); Hoyong Lim, Yongin-si (KR); and Sungyoo Cho, Yongin-si (KR)
Assigned to GC Cell Corporation, Gyeonggi-do (KR)
Filed by GC Cell Corporation, Yongin-si (KR)
Filed on Mar. 27, 2024, as Appl. No. 18/618,414.
Application 18/298,310 is a division of application No. 16/881,650, filed on May 22, 2020, granted, now 11,649,294, issued on May 16, 2023.
Application 18/618,414 is a continuation of application No. 18/298,310, filed on Apr. 10, 2023, granted, now 11,970,547.
Application 16/881,650 is a continuation in part of application No. 16/764,276, granted, now 12,116,417, previously published as PCT/KR2018/013928, filed on Nov. 14, 2018.
Claims priority of application No. 10-2017-0151841 (KR), filed on Nov. 14, 2017.
Prior Publication US 2024/0270872 A1, Aug. 15, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/32 (2006.01); A61K 38/17 (2006.01); A61K 40/15 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C12N 5/0783 (2010.01)
CPC C07K 16/32 (2013.01) [A61K 38/177 (2013.01); A61K 40/15 (2025.01); A61K 40/31 (2025.01); A61K 40/4205 (2025.01); A61P 35/00 (2018.01); C07K 14/705 (2013.01); C12N 5/0646 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/49 (2023.05); A61K 2239/53 (2023.05); C07K 2317/565 (2013.01)] 20 Claims
 
1. A chimeric antigen receptor targeting human HER2, the chimeric antigen receptor comprising an amino acid sequence comprising:
an extracellular antigen binding domain comprising a heavy chain variable region comprising the amino acid sequences of SEQ ID NO: 7, SEQ ID NO: 8, and SEQ ID NO: 9, and a light chain variable region comprising the amino acid sequences of SEQ ID NO: 10, SEQ ID NO: 11, and SEQ ID NO: 12;
a hinge domain;
a transmembrane domain; and
an intracellular signaling domain comprising an OX40L intracellular signaling domain.