US 12,410,257 B2
Monoclonal antibody that binds specifically to GITR
Andrei Borisovich Ulitin, Puschino (RU); Olesya Nikolaevna Kozlova, Saint Petersburg (RU); Aleksandr Andreevich Gordeev, Izhevsk (RU); Ksenia Mihailovna Burnysheva, Moscow (RU); Anastasia Nikolaevna Ishutinova, Chekhov (RU); Aleksandra Aleksandrovna Sozonova, Severodvinsk (RU); Sergei Andreevich Ageev, Chehov (RU); Aleksandr Nikolaevich Doronin, Moscow (RU); Vladimir Sergeevich Tsympilov, Zakulta (RU); Ivan Vladimirovich Mitroshin, Izhevsk (RU); Valery Vladimirovich Solovyev, Pushchino (RU); Iakov Iurevich Ustiugov, Berezniki (RU); Roman Alekseevich Ivanov, Moscow (RU); and Dmitry Valentinovich Morozov, Saint Petersburg (RU)
Appl. No. 17/605,933
Filed by JOINT STOCK COMPANY “BIOCAD”, Saint Petersburg (RU)
PCT Filed Apr. 23, 2020, PCT No. PCT/RU2020/050080
§ 371(c)(1), (2) Date Oct. 22, 2021,
PCT Pub. No. WO2020/218951, PCT Pub. Date Oct. 29, 2020.
Claims priority of application No. RU2019112296 (RU), filed on Apr. 23, 2019.
Prior Publication US 2022/0213209 A1, Jul. 7, 2022
Int. Cl. C07K 16/28 (2006.01); A61P 35/00 (2006.01); C07K 16/46 (2006.01)
CPC C07K 16/2878 (2013.01) [A61P 35/00 (2018.01); C07K 16/46 (2013.01); C07K 2317/21 (2013.01); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/94 (2013.01)] 26 Claims
 
1. An isolated monoclonal antibody or antigen-binding fragment thereof that specifically binds to GITR comprising:
(i)
a heavy chain variable domain that comprises CDR 1, CDR 2 and CDR 3 comprising amino acid sequences represented by the sequences of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO: 3, respectively; and
a light chain variable domain that comprises CDR 1, CDR 2 and CDR 3 comprising amino acid sequences represented by the sequences of SEQ ID NO: 7, SEQ ID NO:8 and SEQ ID NO:9, respectively; or
(ii)
a heavy chain variable domain that comprises CDR 1, CDR 2 and CDR 3 comprising amino acid sequences represented by the sequences of SEQ ID NO: 12, SEQ ID NO: 13 and SEQ ID NO: 14, respectively; and
a light chain variable domain that comprises CDR 1, CDR 2 and CDR 3 comprising amino acid sequences represented by the sequences of SEQ ID NO: 17, SEQ ID NO: 18 and SEQ ID NO: 19, respectively.