	US 12,410,244 B2
	Anti-alpha-synuclein antibodies
Patrick Downey, Brussels (BE); Kerry Louise Tyson, Slough (GB); Marco Kriek, Slough (GB); Lorenzo De Lichtervelde, Brussels (BE); Daniel John Lightwood, Slough (GB); David James Mcmillan, Slough (GB); Peter Charles Elliott, Slough (GB); and Terence Seward Baker, Berkshire (GB)
Assigned to UCB Biopharma SRL, Brussels (BE)
Filed by UCB Biopharma SRL, Brussels (BE)
Filed on Feb. 28, 2022, as Appl. No. 17/682,082.
Application 17/682,082 is a continuation of application No. 16/772,043, granted, now 11,292,831, previously published as PCT/EP2018/084689, filed on Dec. 13, 2018.
Claims priority of application No. 1720970 (GB), filed on Dec. 15, 2017.
Prior Publication US 2022/0340648 A1, Oct. 27, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/18 (2006.01); A61P 25/16 (2006.01); A61K 39/00 (2006.01)

CPC C07K 16/18 (2013.01) [A61P 25/16 (2018.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/92 (2013.01)]

15 Claims

1. A method for detecting alpha synuclein in a biological sample, comprising:

a) contacting the biological sample with an anti-alpha synuclein antibody or antigen-binding fragment thereof, and

b) detecting binding of the anti-alpha synuclein antibody or antigen-binding fragment thereof to alpha synuclein;

wherein the antibody or antigen-binding fragment thereof comprises:

i. a light chain variable region comprising a CDR-L1 comprising SEQ ID NO: 1; a CDR-L2 comprising SEQ ID NO: 2 and a CDR-L3 comprising SEQ ID NO: 3; and a heavy chain variable region comprising a CDR-H1 comprising SEQ ID NO: 4; a CDR-H2 comprising SEQ ID NO: 5 and a CDR-H3 comprising SEQ ID NO: 6; or

ii. a light chain variable region comprising SEQ ID NO: 13 and a heavy chain variable region comprising SEQ ID NO: 25; or a light chain variable region comprising SEQ ID NO: 17 and a heavy chain variable region comprising SEQ ID NO: 25; or a light chain variable region comprising SEQ ID NO: 21 and a heavy chain variable region comprising SEQ ID NO: 25; or

iii. a light chain comprising SEQ ID NO: 14 and a heavy chain comprising SEQ ID SEQ ID NO: 26; or a light chain comprising SEQ ID NO: 18 and a heavy chain comprising SEQ ID SEQ ID NO: 26; or a light chain comprising SEQ ID NO: 22 and a heavy chain comprising SEQ ID SEQ ID NO: 26.