US 12,410,235 B2
I domain chimeric antigen receptor specific to ICAM-1
Moonsoo Jin, New York, NY (US)
Assigned to Cornell University, Ithaca, NY (US)
Filed by Cornell University, Ithaca, NY (US)
Filed on Jun. 21, 2021, as Appl. No. 17/304,412.
Application 17/304,412 is a continuation of application No. 16/582,206, filed on Sep. 25, 2019, granted, now 11,046,748.
Application 16/582,206 is a continuation of application No. 15/675,508, filed on Aug. 11, 2017, granted, now 10,428,136, issued on Oct. 1, 2019.
Claims priority of provisional application 62/383,139, filed on Sep. 2, 2016.
Claims priority of provisional application 62/419,817, filed on Nov. 9, 2016.
Prior Publication US 2021/0309721 A1, Oct. 7, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 1/00 (2006.01); A61K 38/17 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61K 51/08 (2006.01); C07K 14/705 (2006.01); C07K 14/72 (2006.01); C07K 14/725 (2006.01); C12N 5/02 (2006.01); C12N 5/0783 (2010.01); A61K 39/00 (2006.01)
CPC C07K 14/723 (2013.01) [A61K 38/1796 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/421 (2025.01); A61K 51/083 (2013.01); A61K 51/088 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 14/70553 (2013.01); C12N 5/0636 (2013.01); A61K 2039/515 (2013.01); A61K 2039/54 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C07K 2319/03 (2013.01); C07K 2319/74 (2013.01); C12N 2510/00 (2013.01)] 11 Claims
 
1. A Chimeric antigen receptor (CAR) comprising from N-terminus to C-terminus:
(i) an I domain of the αL subunit of human lymphocyte function-associated antigen-1, wherein the I domain is a wild-type I domain consisting of the sequence of 130-310 amino acids of SEQ ID NO: 1, or a mutant thereof having 1 to 3 amino acid mutations at the amino acid residue A 265, 288, 289, 292, 295, or 309 of,
(ii) a transmembrane domain,
(iii) at least one co-stimulatory domains, and
(iv) an activating domain.