	US 12,410,233 B2
	Extracellular domain of alpha subunit of IgE Fc receptor, pharmaceutical composition comprising same and method for producing same
Young Chul Sung, Seoul (KR); Zungyoon Yang, Incheon (KR); and Myung Ho Jang, Seoul (KR)
Assigned to GI Innovation, Inc., Seoul (KR)
Appl. No. 16/958,861
Filed by GI INNOVATION, INC., Seoul (KR)
PCT Filed Jan. 8, 2019, PCT No. PCT/KR2019/000274 § 371(c)(1), (2) Date Jun. 29, 2020, PCT Pub. No. WO2019/135668, PCT Pub. Date Jul. 11, 2019.
Claims priority of application No. 10-2018-0002248 (KR), filed on Jan. 8, 2018.
Prior Publication US 2021/0070833 A1, Mar. 11, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A23L 33/18 (2016.01); A61K 38/00 (2006.01); A61P 37/08 (2006.01); C07K 14/735 (2006.01)

CPC C07K 14/70535 (2013.01) [A23L 33/18 (2016.08); A61P 37/08 (2018.01); A61K 38/00 (2013.01)]

12 Claims

1. A polypeptide dimer, comprising:

two monomers, each of which comprises an extracellular domain of an alpha subunit of an IgE Fc receptor (FcεRIα-ECD) consisting of the amino acid sequence of SEQ ID NO: 1,

wherein each of the two monomers comprises a modified Fc region consisting of the amino acid sequence of SEQ ID NO: 2,

wherein the N-terminus of the modified Fc region is linked via a hinge to the C-terminus of the FcεRIα-ECD to have a structure of N′-FcεRIα-ECD-hinge-modified Fc region-C′, and

wherein the hinge comprises the amino acid sequence of SEQ ID NO: 3.