US 12,410,218 B2
Insecticidal peptide production and combination of cysteine rich peptides
Robert M. Kennedy, Dexter, MI (US); William Tedford, Calgary (CA); Christopher Hendrickson, Los Angeles, CA (US); Robert Venable, Lawrence, MI (US); Catherine L. Foune, Gobles, MI (US); John Mcintyre, Alto, MI (US); Alvar R. Carlson, Kalamazoo, MI (US); and Lin Bao, Portage, MI (US)
Assigned to Vestaron Corporation, Kalamazoo, MI (US)
Filed by Vestaron Corporation, Durham, NC (US)
Filed on Sep. 8, 2022, as Appl. No. 17/930,683.
Application 16/865,193 is a division of application No. 15/390,153, filed on Dec. 23, 2016, granted, now 10,669,319, issued on Jun. 2, 2020.
Application 15/390,153 is a division of application No. 14/383,841, granted, now 9,567,381, issued on Feb. 14, 2017, previously published as PCT/US2013/030042, filed on Mar. 8, 2013.
Application 17/930,683 is a continuation of application No. 16/865,193, filed on May 1, 2020, granted, now 11,472,854.
Claims priority of provisional application 61/729,905, filed on Nov. 26, 2012.
Claims priority of provisional application 61/698,261, filed on Sep. 7, 2012.
Claims priority of provisional application 61/644,212, filed on May 8, 2012.
Claims priority of provisional application 61/608,921, filed on Mar. 9, 2012.
Prior Publication US 2023/0257427 A1, Aug. 17, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/435 (2006.01); A01N 63/50 (2020.01); C12N 15/82 (2006.01)
CPC C07K 14/43518 (2013.01) [A01N 63/50 (2020.01); C07K 14/43504 (2013.01); C12N 15/8286 (2013.01); C07K 2319/55 (2013.01); Y02A 40/146 (2018.01)] 26 Claims
 
1. A combination comprising a Bt toxin selected from the group consisting of: Cry1a, Cry1b, Cry1c, Cry2a, and combinations thereof, and a U+2-ACTX-Hv1a peptide having the amino acid sequence set forth in SEQ ID NO: 5, wherein the Bt toxin and the U+2-ACTX-Hv1a peptide are not fused together as a single fusion protein, wherein the combination is formulated in separate compositions, and wherein the separate compositions of the combination come together and have insecticidal activity.