US 12,410,178 B2
Small cationic ortho-5,15-di-heteroaryl-porphyrin derivatives and their applications in photoinactivation of microorganisms
Maria Miguéns Pereira, Coimbra (PT); Gabriela Conceição Duarte Jorge Da Silva, Coimbra (PT); Luís Guilerme Da Silva Arnaut Moreira, Coimbra (PT); Carolina Dos Santos Vinagreiro, Coimbra (PT); Kate Cristina Blanco, Sao Carlos (PT); Vanderiei Salvador Bagnato, Sao Carlos (PT); and Natalia Mayumi Inada, Sao Carlos (PT)
Assigned to UNIVERSIDADE DE COIMBRA, Coimbra (PT)
Appl. No. 17/618,971
Filed by UNIVERSIDADE DE COIMBRA, Coimbra (PT)
PCT Filed Jun. 15, 2020, PCT No. PCT/IB2020/055584
§ 371(c)(1), (2) Date Dec. 14, 2021,
PCT Pub. No. WO2020/250207, PCT Pub. Date Dec. 17, 2020.
Claims priority of application No. 115581 (PT), filed on Jun. 14, 2019.
Prior Publication US 2022/0372043 A1, Nov. 24, 2022
Int. Cl. C07D 487/22 (2006.01); A61K 31/555 (2006.01); A61K 41/00 (2020.01); A61K 45/06 (2006.01); A61P 31/04 (2006.01)
CPC C07D 487/22 (2013.01) [A61K 31/555 (2013.01); A61K 41/0057 (2013.01); A61K 45/06 (2013.01); A61P 31/04 (2018.01)] 12 Claims
 
1. Cationic ortho-5,15-di-heteroaryl porphyrin derivatives, namely chlorins or bacteriochlorins of Formula I:

OG Complex Work Unit Chemistry
wherein:
custom character represents a carbon-carbon single bond or a carbon-carbon double bond, wherein at least one custom character represents a carbon-carbon single bond
M is H2 or a metal ion selected from Mg, Al, Si, Zn, Pd, Ag, In;
R and R′ are independently chosen from unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, provided that R and R′ have fewer than 12 atoms;
or pharmaceutically acceptable salts thereof.