US 12,410,177 B2
Antimicrobial and anticancer cationic phthalocyanine compounds
Paul Wight, Manchester (GB)
Assigned to BMG (BRITISH MEDICAL GROUP) LIMITED, Cambridge (GB)
Appl. No. 17/046,108
Filed by BMG (BRITISH MEDICAL GROUP) LIMITED, Cambridge (GB)
PCT Filed Apr. 9, 2019, PCT No. PCT/EP2019/058986
§ 371(c)(1), (2) Date Oct. 8, 2020,
PCT Pub. No. WO2019/197419, PCT Pub. Date Oct. 17, 2019.
Claims priority of application No. 18166408 (EP), filed on Apr. 9, 2018.
Prior Publication US 2021/0032261 A1, Feb. 4, 2021
Int. Cl. C07D 487/22 (2006.01); A41D 19/00 (2006.01); A41D 31/30 (2019.01); C11D 3/16 (2006.01); C11D 3/48 (2006.01)
CPC C07D 487/22 (2013.01) [A41D 19/0055 (2013.01); A41D 31/30 (2019.02); C11D 3/168 (2013.01); C11D 3/48 (2013.01)] 5 Claims
 
1. A population of compounds comprising compounds according to one or more of formulas Cs, C4h, D2h and C2v below:

OG Complex Work Unit Chemistry
wherein in each of the above formulas:
each occurrence of R is independently R′ or R″, where there is a mean average of (a) occurrences of R′ and (b) occurrences of R″ in each formula; and a+b=4;
R′ is 3-oxygen linked pyridyl having the following structure:

OG Complex Work Unit Chemistry
R″ is 3-oxygen linked N-alkylated pyridinium having the following structure:

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wherein the mean average total number of substituent R″ (b) is from 1 to 3.9;
M is selected from aluminium or zinc;
each formula has counterions X selected from Cl−, Br−, I−, methanesulphonate, ethanesulphonate, formate, acetate or other inorganic or organic counter-ion or mixture thereof; and
wherein R′″ is optionally branched C1-C8 alkyl,
and wherein the population of compounds comprises a compound having the following structure:

OG Complex Work Unit Chemistry