US 12,410,167 B2
Pyridazine compounds for inhibiting NLRP3
Stéphane Dorich, Pointe-Claire (CA); Jason Burch, Pointe-Claire (CA); Miguel St-Onge, Saint-Lazare (CA); Amandine Chefson, Montreal (CA); Alexandre Côté, Laval (CA); Ramsay Beveridge, Pointe-Claire (CA); and Stéphane Ciblat, Montreal (CA)
Assigned to Ventus Therapeutics U.S., Inc., Waltham, MA (US)
Filed by Ventus Therapeutics U.S., Inc., Waltham, MA (US)
Filed on Oct. 3, 2023, as Appl. No. 18/480,164.
Application 18/480,164 is a continuation of application No. PCT/US2022/023893, filed on Apr. 7, 2022.
Claims priority of provisional application 63/171,932, filed on Apr. 7, 2021.
Prior Publication US 2024/0199606 A1, Jun. 20, 2024
Int. Cl. C07D 471/04 (2006.01); A61K 31/501 (2006.01); A61K 31/502 (2006.01); A61K 31/5025 (2006.01); A61K 31/5377 (2006.01); C07D 405/12 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01); C07D 519/00 (2006.01)
CPC C07D 471/04 (2013.01) [A61K 31/501 (2013.01); A61K 31/502 (2013.01); A61K 31/5025 (2013.01); A61K 31/5377 (2013.01); C07D 405/12 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01); C07D 519/00 (2013.01)] 17 Claims
 
1. A compound of Formula (II):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, stereoisomer, or tautomer thereof;
wherein:
Y is phenyl independently substituted with one, two, or three substituents selected from the group consisting of C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, halo, cyano, and —R4OR5, wherein at least one substitution is substituted at the para-position of the phenyl ring;
R1 is C1-C6 alkyl independently substituted with one or more halo and —R4OR5;
R2 and R3, together with the atoms to which they are attached, form a 5- to 9-membered heteroaryl optionally substituted with one or more R2a;
R2a is hydrogen, C1-C6 alkyl, halo or C1-C6 haloalkyl;
R4 is absent, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl; and
R5 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, 3- to 8-membered heterocycloalkyl, C5-C10 aryl, or 5- to 9-membered heteroaryl.