US 12,410,122 B2
Lipid formulations for gene editing
Kallanthottathil G. Rajeev, Wayland, MA (US); and Souvik Biswas, Woburn, MA (US)
Assigned to VERVE THERAPEUTICS, INC., Boston, MA (US)
Filed by Verve Therapeutics, Inc., Boston, MA (US)
Filed on May 3, 2024, as Appl. No. 18/654,660.
Application 18/654,660 is a continuation of application No. 18/180,306, filed on Mar. 8, 2023, granted, now 12,024,484.
Application 18/180,306 is a continuation of application No. PCT/US2021/050511, filed on Sep. 15, 2021.
Claims priority of provisional application 63/220,340, filed on Jul. 9, 2021.
Claims priority of provisional application 63/078,738, filed on Sep. 15, 2020.
Prior Publication US 2024/0368071 A1, Nov. 7, 2024
Int. Cl. A61K 47/54 (2017.01); C07C 229/12 (2006.01); C07C 229/14 (2006.01)
CPC C07C 229/12 (2013.01) 27 Claims
 
1. A nanoparticle composition that comprises an amino lipid, or a pharmaceutically acceptable salt or solvate thereof, wherein the amino lipid has a structure selected from:

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wherein m is selected from 1 to 10.