US 12,409,441 B2
Method of preparing polymer-filled chromatography resin
James Wei Xu, Basking Ridge, NJ (US); Jiali Liao, San Ramon, CA (US); Christopher Belisle, Walnut Creek, CA (US); Fang Song, Wuxi (CN); Haihui Yuan, Nantong (CN); Juan You, Wuxi (CN); Wenli Cao, Wuxi (CN); and Xiaozhong Bao, Wuxi (CN)
Assigned to Bio-Rad Laboratories, Inc., Hercules, CA (US)
Appl. No. 17/800,515
Filed by Bio-Rad Laboratories, Inc., Hercules, CA (US)
PCT Filed Feb. 19, 2020, PCT No. PCT/CN2020/075807
§ 371(c)(1), (2) Date Aug. 17, 2022,
PCT Pub. No. WO2021/163910, PCT Pub. Date Aug. 26, 2021.
Prior Publication US 2023/0087779 A1, Mar. 23, 2023
Int. Cl. B01J 20/32 (2006.01); B01J 20/286 (2006.01); B01J 20/30 (2006.01)
CPC B01J 20/3204 (2013.01) [B01J 20/286 (2013.01); B01J 20/3057 (2013.01); B01J 2220/86 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A method of preparing a polymer-filled chromatography resin, the method comprising:
adding a chromatography resin to a solution comprising melted polymer while stirring to allow the melted polymer to absorb or otherwise enter the pores of the chromatography resin;
atomizing the solution and collecting insoluble porous polymer-filled chromatography resin beads in a water bath; and
removing excess polymer from the insoluble porous polymer-filled chromatography resin beads.