US 12,409,314 B2
Pump system, control unit and method for operating a pump system
Robert Steingräber, Berlin (DE); Matthias Kiesner, Rangsdorf (DE); Alexander Reiprich, Lychen (DE); and John C. Woodard, Turramurra (AU)
Assigned to Berlin Heart GmbH, Berlin (DE)
Appl. No. 17/775,835
Filed by Berlin Heart GmbH, Berlin (DE)
PCT Filed Nov. 11, 2020, PCT No. PCT/EP2020/081735
§ 371(c)(1), (2) Date May 10, 2022,
PCT Pub. No. WO2021/094359, PCT Pub. Date May 20, 2021.
Claims priority of application No. 19208405 (EP), filed on Nov. 11, 2019.
Prior Publication US 2022/0387780 A1, Dec. 8, 2022
Int. Cl. A61M 60/546 (2021.01); A61M 60/122 (2021.01); A61M 60/268 (2021.01); A61M 60/427 (2021.01); A61M 60/515 (2021.01); A61M 60/562 (2021.01); A61M 60/585 (2021.01)
CPC A61M 60/546 (2021.01) [A61M 60/122 (2021.01); A61M 60/268 (2021.01); A61M 60/427 (2021.01); A61M 60/515 (2021.01); A61M 60/562 (2021.01); A61M 60/585 (2021.01); A61M 2205/3331 (2013.01); A61M 2230/04 (2013.01); A61M 2230/63 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A pump system comprising
a diaphragm fluid pump which can be fluidically connected to a heart and/or at least one blood vessel by means of an inlet cannula and an outlet cannula and is adapted for generating a pulsatile fluid flow for supporting a cardiac activity of the heart,
a working pressure source connected to the diaphragm fluid pump by means of a pressure line and adapted for providing a working pressure for driving the diaphragm fluid pump,
a control unit adapted for controlling the working pressure,
a first flow sensor adapted for detecting a first cannula flow signal corresponding to an inlet flow in the inlet cannula or an outlet flow in the outlet cannula,
a working pressure sensor adapted for detecting a working pressure signal corresponding to the working pressure in the pressure line,
the pulsatile fluid flow comprising a plurality of consecutive pumping cycles, the cardiac activity comprising a plurality of consecutive cardiac cycles, and each of the pumping cycles comprising a filling phase and an emptying phase,
wherein the control unit is further adapted
to determine a time offset between a first point in time that occurs during a first pumping cycle and a second point in time that occurs during a first cardiac cycle,
to determine a hemodynamic parameter set, comprising one or more hemodynamic parameters, based on the time offset and/or the first cannula flow signal and/or the working pressure signal, and
based on a control specification as a specification for the hemodynamic parameter set and/or for the time offset, to determine a time specification as a specification for a beginning and/or a duration of the filling phase and/or the emptying phase of the first pumping cycle and/or at least one second pumping cycle that occurs temporally after the first pumping cycle such that the control specification is achieved.