| CPC A61M 31/002 (2013.01) [A61K 9/0024 (2013.01); A61K 9/0034 (2013.01); A61K 31/137 (2013.01); A61K 31/167 (2013.01); A61K 31/216 (2013.01); A61K 31/337 (2013.01); A61K 31/407 (2013.01); A61K 31/438 (2013.01); A61K 31/555 (2013.01); A61K 31/7068 (2013.01); A61K 33/243 (2019.01); A61M 31/00 (2013.01); A61M 31/007 (2013.01); A61K 31/46 (2013.01); A61M 2205/04 (2013.01); A61M 2210/1085 (2013.01)] | 49 Claims |

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1. A method of providing controlled release of drug to a patient, comprising:
deploying into the patient, a drug delivery device comprising (i) a closed drug reservoir lumen bounded by a first wall structure constructed of a first material and by a second wall structure constructed of a second material, and (ii) a solid drug formulation which comprises a drug and is contained in the closed drug reservoir lumen,
wherein water in the patient diffuses through the first and second wall structures into the closed drug reservoir lumen to contact and solubilize the drug formulation,
wherein the drug is released from the drug delivery device, via diffusion through only the second wall structure, and
wherein the first material and the second material are two different polymeric materials.
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