US 12,409,263 B2
System and method for estimation and control of compliance and pressure/volume variations within a body cavity
Anders Rosendal Korshøj, Risskov (DK); Peter Gorm Larsen, Hinnerup (DK); Peter Johansen, Risskov (DK); and René Søndergaard Nilsson, Aarhus V (DK)
Assigned to Aarhus Universitet, Aarhus C (DK)
Appl. No. 17/278,352
Filed by Aarhus Universitet, Aarhus C (DK)
PCT Filed Sep. 25, 2019, PCT No. PCT/EP2019/075935
§ 371(c)(1), (2) Date Mar. 22, 2021,
PCT Pub. No. WO2020/064875, PCT Pub. Date Apr. 2, 2020.
Claims priority of application No. 18196550 (EP), filed on Sep. 25, 2018.
Prior Publication US 2021/0369941 A1, Dec. 2, 2021
Int. Cl. A61M 1/00 (2006.01); G16H 20/17 (2018.01)
CPC A61M 1/777 (2021.05) [A61M 2205/3303 (2013.01); A61M 2205/3334 (2013.01); A61M 2210/0693 (2013.01); G16H 20/17 (2018.01)] 26 Claims
OG exemplary drawing
 
1. A bio-liquid replacement system for controlled infusion, effusion, and/or perfusion of a biological liquid or a biocompatible liquid to and from a body cavity of a subject, comprising:
at least one sensor for continuously measuring at least one parameter associated with the body cavity,
a pump unit for infusing the biological liquid or the biocompatible liquid into the body cavity and aspirating the biological liquid or the biocompatible liquid out of the body cavity,
a processing unit configured for continuously 1) calculating at least one physiological parameter based on the at least one measured parameter, and 2) defining at least one target parameter, such that the at least one target parameter is slightly offset from the at least one physiological parameter in a time varying manner, and
a flow controller configured for controlling said pump unit based on said at least one target parameter such that continuous compensatory changes are induced in a liquid volume in the body cavity,
wherein the processing unit is configured for continuously estimating a compliance within the body cavity based on said at least one calculated physiological parameter; and
wherein the compliance is estimated as

OG Complex Work Unit Math
 where Δv(k)=vinfusion(k)−vaspiration(k) is a net perfusion flow rate at time k in a time interval [t, ts(t)], ƒp(t) is a value of a function, ƒ, of a measured pressure, p, at time t, ƒp(ts(t)) is a value of the function, ƒ, of the measured pressure, p, at time ts(t).