US 12,409,254 B2
Catheter insert devices
Maria Kim, Ann Arbor, MI (US); Elizabeth J. Brisbois, Athens, GA (US); Joshua C. Doverspike, Ann Arbor, MI (US); Shale J. Mack, Ann Arbor, MI (US); Orsolya I. Lautner-Csorba, Ann Arbor, MI (US); Kamila Katarzyna Konopinska, Vista, CA (US); and Mark E. Meyerhoff, Ann Arbor, MI (US)
Assigned to The Regents of the University of Michigan, Ann Arbor, MI (US)
Appl. No. 17/617,507
Filed by THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
PCT Filed Jun. 9, 2020, PCT No. PCT/US2020/036823
§ 371(c)(1), (2) Date Dec. 8, 2021,
PCT Pub. No. WO2020/251947, PCT Pub. Date Dec. 17, 2020.
Claims priority of provisional application 62/859,515, filed on Jun. 10, 2019.
Prior Publication US 2022/0218880 A1, Jul. 14, 2022
Int. Cl. A61L 29/16 (2006.01); A61L 29/02 (2006.01); A61L 29/06 (2006.01); A61M 25/00 (2006.01)
CPC A61L 29/16 (2013.01) [A61L 29/02 (2013.01); A61L 29/06 (2013.01); A61M 25/0043 (2013.01); A61L 2300/114 (2013.01); A61L 2300/60 (2013.01); A61M 2025/0056 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A catheter insert device, comprising:
a powder composition including a solid phase S-nitrosothiol (RSNO);
a housing, including:
a polymeric wall that is i) permeable to nitric oxide, ii) non-porous, and iii) permeable to water vapor; and
an inner lumen defined at least in part by the polymeric wall;
wherein the powder composition is completely sealed within the inner lumen of the housing; and
a solid phase additive completely sealed within the inner lumen of the housing, wherein the solid phase additive is a metal wire.