US 12,409,232 B2
Temperature-responsive drug/polymer compound and application of compound to drug delivery
Kanjiro Miyata, Tokyo (JP); Beob Soo Kim, Tokyo (JP); Shigehito Osawa, Tokyo (JP); Mitsuru Naito, Tokyo (JP); and Hiroyuki Chaya, Tokyo (JP)
Assigned to The University of Tokyo, Tokyo (JP)
Appl. No. 17/628,676
Filed by The University of Tokyo, Tokyo (JP)
PCT Filed Jul. 27, 2020, PCT No. PCT/JP2020/028698
§ 371(c)(1), (2) Date Jun. 29, 2022,
PCT Pub. No. WO2021/020342, PCT Pub. Date Feb. 4, 2021.
Claims priority of provisional application 62/878,970, filed on Jul. 26, 2019.
Prior Publication US 2022/0331439 A1, Oct. 20, 2022
Int. Cl. A61K 47/61 (2017.01); A61K 9/107 (2006.01); A61K 47/54 (2017.01); A61K 47/55 (2017.01)
CPC A61K 47/61 (2017.08) [A61K 9/1075 (2013.01); A61K 47/545 (2017.08); A61K 47/55 (2017.08)] 20 Claims
OG exemplary drawing
 
1. A drug-polymer conjugate having thermoresponsiveness, comprising:
at least one thermoresponsive polymer segment; and
at least one drug covalently bound to at least one end of the at least one thermoresponsive polymer segment,
the drug-polymer conjugate having a lower critical solution temperature.