	US 12,409,228 B2
	Hydrogel drug delivery systems for the treatment of pediatric growth plate injuries
Karin A. Payne, Denver, CO (US); and Melissa D. Krebs, Englewood, CO (US)
Assigned to The Regents of the University of Colorado, a body corporate, Denver, CO (US); and Colorado School of Mines, Golden, CO (US)
Filed by THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, Denver, CO (US); and COLORADO SCHOOL OF MINES, Golden, CO (US)
Filed on Dec. 21, 2023, as Appl. No. 18/392,543.
Application 18/392,543 is a continuation of application No. 16/762,860, abandoned, previously published as PCT/US2018/059460, filed on Nov. 6, 2018.
Claims priority of provisional application 62/583,047, filed on Nov. 8, 2017.
Prior Publication US 2024/0238421 A1, Jul. 18, 2024
Int. Cl. A61K 47/36 (2006.01); A61B 17/16 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 47/22 (2006.01); A61L 27/20 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); A61P 19/00 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); C07K 16/22 (2006.01); C08J 3/075 (2006.01)

CPC A61K 47/36 (2013.01) [A61K 9/0019 (2013.01); A61K 9/06 (2013.01); A61K 47/22 (2013.01); A61L 27/20 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61P 19/00 (2018.01); A61P 19/08 (2018.01); C07K 16/22 (2013.01); C08J 3/075 (2013.01); A61B 17/16 (2013.01); A61L 2300/256 (2013.01); A61L 2300/412 (2013.01); A61L 2300/414 (2013.01); A61L 2300/416 (2013.01); A61L 2300/62 (2013.01); A61L 2430/06 (2013.01); A61P 19/10 (2018.01); C08J 2305/04 (2013.01); C08J 2305/08 (2013.01)]

19 Claims

1. A method of treating a growth plate injury in a subject, the method comprising administering to the subject, a therapeutically effective amount of a hydrogel composition consisting of at least one hydrogel polymer material selected from the group consisting of chitosan, alginate and a combination thereof, at least one biological factor selected from the group consisting of anti-VEGF compounds, stem cell attracting factors, and transforming growth factor beta cytokines; and optionally hyaluronic acid; and treating the growth plate injury in the subject.