US 12,409,205 B2
Nanomolecules for the treatment of inflammatory bowel diseases
Arun Sharma, Elmwood Park, IL (US)
Assigned to Northwestern University, Evanston, IL (US)
Appl. No. 17/047,299
Filed by Northwestern University, Evanston, IL (US)
PCT Filed Apr. 12, 2019, PCT No. PCT/US2019/027291
§ 371(c)(1), (2) Date Oct. 13, 2020,
PCT Pub. No. WO2019/200298, PCT Pub. Date Oct. 17, 2019.
Claims priority of provisional application 62/657,361, filed on Apr. 13, 2018.
Prior Publication US 2021/0113650 A1, Apr. 22, 2021
Int. Cl. A61K 38/10 (2006.01); A61B 1/015 (2006.01); A61B 1/31 (2006.01); A61K 38/08 (2019.01); A61K 47/54 (2017.01); A61K 47/64 (2017.01); A61K 49/00 (2006.01); A61M 5/178 (2006.01); A61P 1/00 (2006.01); A61P 29/00 (2006.01)
CPC A61K 38/10 (2013.01) [A61B 1/015 (2013.01); A61B 1/31 (2013.01); A61K 38/08 (2013.01); A61K 47/545 (2017.08); A61K 47/64 (2017.08); A61K 47/641 (2017.08); A61K 49/0056 (2013.01); A61M 5/178 (2013.01); A61P 1/00 (2018.01); A61P 29/00 (2018.01); A61M 2210/1057 (2013.01); A61M 2210/106 (2013.01); A61M 2210/1064 (2013.01)] 19 Claims
 
1. A composition comprising branched peptide amphiphiles comprising:
(a) a single nanofiber-forming moiety comprising: (i) a hydrophobic segment, a structural segment, and a charged segment, wherein the nanofiber-forming moiety self- assembles under aqueous conditions with other similar nanofiber-forming moieties to form a peptide amphiphile nanofiber;
(b) an anti-inflammatory (AIF) peptide;
(c) an additional functional moiety selected from a targeting moiety and a visualization moiety; and
(d) a branchpoint, wherein the branchpoint is linked to the single nanofiber- forming moiety, the AIF peptide, and the additional functional moiety.