	US 12,409,204 B1
	Compositions and methods for hair treatment
Jacob J. Miguel, Pinecrest, FL (US); Spencer Bouhadir, Lake Worth, FL (US); and Jacob A. Miguel, Pinecrest, FL (US)
Assigned to NEUVIAN IP HOLDINGS, LLC, Pinecrest, FL (US)
Filed by Neuvian Skincare, LLC, Pinecrest, FL (US)
Filed on Mar. 8, 2024, as Appl. No. 18/600,574.
Int. Cl. A61K 38/06 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/24 (2006.01); A61K 47/36 (2006.01); A61K 47/40 (2006.01); A61P 17/14 (2006.01)

CPC A61K 38/06 (2013.01) [A61K 45/06 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/24 (2013.01); A61K 47/36 (2013.01); A61K 47/40 (2013.01); A61P 17/14 (2018.01)]

26 Claims

1. A composition for altering gene expression of a cell in a human subject comprising:

(a) a glycyl-L-histidyl-L-lysine copper (GHK-Cu) peptide;

(b) an antioxidant selected from the group consisting of L-carnosine, D-carnosine, acetyl-carnosine, and combinations thereof, and

wherein the GHK-Cu peptide and the antioxidant form a complex and the complex is entrapped by the cyclodextran; and

wherein the composition is effective to decrease the gene expression of one or more of the genes hSDF-1, hAR, hSRD5A1, and hSRD5A3, and/or increase expression of TGF-β2.