	US 12,409,202 B2
	Autonomic nerve regulator and cognitive function improver
Ryota Akagi, Kobe (JP); Toshinari Maruo, Kobe (JP); Narumi Mori, Kobe (JP); and Toshio Suzuki, Kobe (JP)
Assigned to FUJICCO CO., LTD., Hyogo (JP)
Filed by FUJICCO CO., LTD., Hyogo (JP)
Filed on Jul. 29, 2022, as Appl. No. 17/876,955.
Claims priority of application No. 2021-125497 (JP), filed on Jul. 30, 2021.
Prior Publication US 2023/0050805 A1, Feb. 16, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 36/48 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61P 25/28 (2006.01)

CPC A61K 36/48 (2013.01) [A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61K 9/4858 (2013.01); A61K 9/4875 (2013.01); A61P 25/28 (2018.01)]

8 Claims

1. A method for modulating an autonomic nervous system, comprising administering an effective amount of a black soybean seed coat extract to a subject in need thereof, wherein the black soybean seed coat extract is an extract of black soybean seed coat obtained by using water containing sulfuric acid as an extraction solvent,

wherein the black soybean seed coat extract contains 30% w/w or more of polyphenols, wherein the polyphenols include cyanidin 3-glucoside, proanthocyanidins, catechin and epicatechin collectively in an amount of 10% w/w or more of the black soybean seed coat extract, and

wherein the black soybean seed coat extract comprises a lower concentration of cyanidin 3-glucoside as compared to a total concentration of 2-mer to 9-mer proanthocyanidins.