US 12,409,182 B2
Compositions and uses thereof for treatment of idiopathic preterm birth
Charles Lockwood, Tampa, FL (US); Ozlem Guzeloglu-Kayisli, Wesley Chapel, FL (US); Umit Ali Kayisli, Wesley Chapel, FL (US); and Frederick Schatz, Tampa, FL (US)
Assigned to UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US)
Filed by UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US)
Filed on Nov. 6, 2023, as Appl. No. 18/502,589.
Application 18/502,589 is a division of application No. 17/479,523, filed on Sep. 20, 2021, granted, now 11,806,356.
Claims priority of provisional application 63/161,611, filed on Mar. 16, 2021.
Claims priority of provisional application 63/080,462, filed on Sep. 18, 2020.
Prior Publication US 2024/0082261 A1, Mar. 14, 2024
Int. Cl. A61K 31/557 (2006.01); A61K 31/201 (2006.01); A61P 15/06 (2006.01)
CPC A61K 31/557 (2013.01) [A61K 31/201 (2013.01); A61P 15/06 (2018.01)] 20 Claims
OG exemplary drawing
 
1. A method of delaying or preventing an idiopathic preterm birth in a subject, comprising
a) determining whether a biological sample obtained from the subject has an altered level of 9-nitro-9E-octadecenoic acid or 10-nitro-9E-octadecenoic acid as compared to a control; and
b) administering to the subject a therapeutically effective amount of a composition comprising 15-deoxy-Δ12,14-prostaglandin J2 or a derivative thereof if the biological sample obtained from the subject has an altered level of 9-nitro-9E-octadecenoic acid or 10-nitro-9E-octadecenoic acid as compared to the control.