US 12,409,175 B2
Method of increasing bioavailability and/or prolonging ophthalmic action of a drug
Ajay Jaysingh Khopade, Baroda (IN); and Arindam Halder, Baroda (IN)
Assigned to SUN PHARMA ADVANCED RESEARCH COMPANY LTD., Mumbai (IN)
Filed by Sun Pharma Advanced Research Company Ltd., Mumbai (IN)
Filed on Feb. 14, 2024, as Appl. No. 18/441,901.
Application 18/441,901 is a continuation of application No. 18/061,848, filed on Dec. 5, 2022, granted, now 11,931,359.
Application 18/061,848 is a continuation of application No. 17/304,309, filed on Jun. 17, 2021, granted, now 11,951,106.
Application 17/304,309 is a continuation of application No. 16/180,731, filed on Nov. 5, 2018, granted, now 11,058,684, issued on Jul. 13, 2021.
Application 16/180,731 is a continuation of application No. 15/329,824, granted, now 10,172,852, issued on Jan. 8, 2019, previously published as PCT/IN2015/050076, filed on Jul. 24, 2015.
Claims priority of application No. 2437/MUM/2014 (IN), filed on Jul. 28, 2014; and application No. 2206/MUM/2015 (IN), filed on Jun. 9, 2015.
Prior Publication US 2024/0180902 A1, Jun. 6, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/498 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/16 (2006.01); A61K 9/51 (2006.01); A61K 45/06 (2006.01); B01J 39/20 (2006.01)
CPC A61K 31/498 (2013.01) [A61K 9/0048 (2013.01); A61K 9/0051 (2013.01); A61K 9/08 (2013.01); A61K 9/1635 (2013.01); A61K 9/5176 (2013.01); A61K 45/06 (2013.01); B01J 39/20 (2013.01)] 14 Claims
 
1. An aqueous suspension comprising reversible clusters of drug loaded ion-exchange resin particles, said clusters have a D50 value of at least 2 micrometers and the drug loaded ion-exchange resin particles have a particle size distribution characterized in that the D90 value is 70 to 900 nanometers, wherein the drug is brimonidine tartrate, and the brimonidine tartrate is present at a concentration of 0.35% w/v.