US 12,409,121 B2
Formulations and methods for preparing stable cosmetic compositions
Garrett Reynolds, Colts Neck, NJ (US)
Assigned to Spinart, LLC, Hazlet, NJ (US)
Filed by Spinart, LLC, Hazlet, NJ (US)
Filed on May 5, 2020, as Appl. No. 16/867,370.
Claims priority of provisional application 62/844,061, filed on May 6, 2019.
Prior Publication US 2020/0352840 A1, Nov. 12, 2020
Int. Cl. A61K 8/44 (2006.01); A61K 8/365 (2006.01); A61K 8/368 (2006.01); A61K 8/37 (2006.01); A61Q 5/00 (2006.01); A61Q 7/02 (2006.01); A61Q 17/04 (2006.01); A61Q 19/08 (2006.01)
CPC A61K 8/44 (2013.01) [A61K 8/365 (2013.01); A61K 8/368 (2013.01); A61K 8/375 (2013.01); A61Q 5/006 (2013.01); A61Q 7/02 (2013.01); A61Q 17/04 (2013.01); A61Q 19/08 (2013.01); A61K 2800/30 (2013.01); A61K 2800/524 (2013.01); A61K 2800/58 (2013.01); A61K 2800/59 (2013.01)] 8 Claims
 
1. A cosmetic or dermatologic composition raw material containing an arginine-component comprising
i) a complex consisting essentially of an arginine compound and one carboxylic acid selected from anisic acid, levulinic acid, mandelic acid, sorbic acid, benzoic acid, ferulic acid, and syringic acid or two carboxylic acids selected from anisic acid, levulinic acid, mandelic acid, salicylic acid, sorbic acid, benzoic acid, ferulic acid, and syringic acid, wherein said complex does not comprise a humectant, and
ii) a solvent;
wherein the arginine compound is an arginine, a conjugate, or an analog thereof represented by Formula VI,

OG Complex Work Unit Chemistry
wherein
R1 represents
a hydrogen atom, a hydroxyl group, an acyl or acyloxy radical, or an amino acid substituted or not on its free a-amino function, bound by a peptide bond;
R2 represents
a hydroxyl group, an amine, alkylamine or alcoxy radical, a silyloxy group, or an amino acid substituted or not on its free α-carboxylic function, bound by a peptide bond;
n represents 3 or 4;
wherein properties of the raw material include:
solubilization of each of the one or two carboxylic acids by the complex;
a humectant with water-attracting properties is unnecessary to stabilize the organic acids in solution, wherein the humectant is a glycerol, a glycol, an ester of polyglycerol, a glycolic ester, and/or an ester of sorbitan;
pH of the raw material ranges from 4.0 to 7.0, inclusive;
the raw material remains clear over multiple freeze thaw cycles;
preservation of a finished cosmetic and dermatologic product by reduction of its decomposition due to chemical change or action of microbes, bacteria, fungi, yeast or a combination thereof without addition of a chemical preservative; and
stabilization of the finished cosmetic and dermatologic product at pH 4.5-5.5. inclusive.