	US 12,409,116 B2
	Lycopene compositions and methods for protecting skin against ultraviolet radiation
Jean Krutmann, Düsseldorf (DE); Yoav Sharoni, Omer (IL); Joseph Levy, Omer (IL); and Karin Linnewiel Hermoni, Tenafly, NJ (US)
Assigned to LYCORED LTD., Be'er Sheva (IL)
Filed by LYCORED LTD., Be'er Sheva (IL)
Filed on May 27, 2024, as Appl. No. 18/674,999.
Application 18/674,999 is a division of application No. 17/262,198, abandoned, previously published as PCT/IL2019/050833, filed on Jul. 23, 2019.
Claims priority of provisional application 62/701,899, filed on Jul. 23, 2018.
Prior Publication US 2024/0307278 A1, Sep. 19, 2024
Int. Cl. A61K 8/31 (2006.01); A23L 33/15 (2016.01); A61K 8/365 (2006.01); A61K 9/00 (2006.01); A61K 31/015 (2006.01); A61K 31/191 (2006.01); A61K 31/355 (2006.01); A61Q 19/08 (2006.01)

CPC A61K 8/31 (2013.01) [A23L 33/15 (2016.08); A61K 8/365 (2013.01); A61K 9/0053 (2013.01); A61K 31/015 (2013.01); A61K 31/191 (2013.01); A61K 31/355 (2013.01); A61Q 19/08 (2013.01); A61K 2800/522 (2013.01); A61K 2800/92 (2013.01)]

15 Claims

1. A method for improving one or more skin parameters in a subject in need thereof, comprising the step of administering to said subject a therapeutically effective amount of a composition comprising (a) lycopene; (b) phytoene and phytofluene; and (c) carnosic acid, wherein the weight ratio of (a) to (b) is from 1:0.3 to 1:0.6 and the weight ratio of (a) to (c) is from 1:0.1 to 1:0.4, and wherein said composition synergistically inhibits ultraviolet B (UVB)-induced interleukin 6 (IL-6) release, thereby improving one or more skin parameters in the subject.