US 12,409,053 B2
Degradable biomedical magnesium alloy drug-eluting vascular stent and preparation method
Hefei Ren, Beijing (CN); Xin Shen, Beijing (CN); Dongyun Hao, Beijing (CN); Yanan Li, Beijing (CN); Jia She, Beijing (CN); Fusheng Pan, Beijing (CN); Fugui He, Beijing (CN); Xiaoyi Ma, Beijing (CN); and Lifeng Zhou, Beijing (CN)
Assigned to AmsinoMed Medical Co., Ltd, Beijing (CN)
Filed by AmsinoMed Medical Co., Ltd, Beijing (CN)
Filed on Aug. 14, 2024, as Appl. No. 18/804,861.
Application 18/804,861 is a continuation of application No. PCT/CN2022/133109, filed on Nov. 21, 2022.
Claims priority of application No. 202210131931.X (CN), filed on Feb. 14, 2022.
Prior Publication US 2024/0398593 A1, Dec. 5, 2024
Int. Cl. A61F 2/915 (2013.01); A61L 31/08 (2006.01)
CPC A61F 2/915 (2013.01) [A61F 2002/91575 (2013.01); A61F 2210/0004 (2013.01); A61F 2210/0009 (2013.01); A61F 2210/0076 (2013.01); A61F 2230/0006 (2013.01); A61F 2230/0069 (2013.01); A61F 2240/001 (2013.01); A61F 2250/0039 (2013.01); A61F 2250/0067 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A degradable biomedical magnesium alloy drug-eluting vascular stent, comprising a stent substrate, and a polymer intermediate layer, a polymer protective layer, and a drug coating layer arranged from inside to outside of the stent substrate, wherein the stent substrate comprises the following components in percentage by weight: 3.0-6.0% of Gd, 2.5-5.5% of Y, 0.3-1.0% of Zn, 0.2-1.0% of Zr and balance of Mg, with regard to a total weight of the stent substrate of 100%;
wherein the polymer of the polymer protective layer is polyvinylidene fluoride and a copolymer thereof; and the polymer protective layer has a thickness of 2 μm-10 μm;
wherein the vascular stent further comprises a drug coating layer provided on the outer surface of the polymer protective layer; the drug coating layer comprises a polymer carrier and an active drug; the active drug is a combination of tacrolimus and one selected from rapamycin and arsenic trioxide;
wherein the weight ratio of arsenic trioxide or rapamycin to tacrolimus is 1:2-4:1.