| CPC A61F 2/2412 (2013.01) [A61F 2/2409 (2013.01); A61F 2/2418 (2013.01); A61F 2/2427 (2013.01); A61F 2/2445 (2013.01); A61F 2/246 (2013.01); A61F 2210/0014 (2013.01); A61F 2220/0008 (2013.01); A61F 2220/0016 (2013.01); A61F 2230/0069 (2013.01); A61F 2250/006 (2013.01); A61F 2250/0063 (2013.01)] | 21 Claims |

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1. A prosthetic heart valve for implantation at a native valve of a heart, the prosthetic heart valve comprising:
a multi-part frame comprising:
a first annular body comprising a plurality of struts arranged in a lattice pattern and defining a lumen, wherein the first annular body has an inflow end portion and an outflow end portion; and
an anchor component comprising a second annular body circumscribing the first annular body and one or more ventricular anchors extending from the second annular body toward the inflow end portion of the first annular body, wherein the one or more ventricular anchors are configured to be positioned behind native valve leaflets;
a fabric layer disposed on an inner surface of the first annular body and sutured to the struts;
a valve structure comprising three leaflets made from pericardium, wherein the valve structure is disposed within the lumen and inlet ends of the leaflets are sutured to the fabric layer; and
wherein the multi-part frame is radially compressible for delivery within a sheath of a delivery catheter and is self-expandable for deployment within an annulus of the native valve.
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