US 12,408,979 B2
Methods and apparatus for selective tissue ablation
Steven R. Mickelsen, Iowa City, IA (US)
Assigned to Boston Scientific Scimed, Inc., Maple Grove, MN (US)
Filed by Boston Scientific Scimed, Inc., Maple Grove, MN (US)
Filed on May 24, 2024, as Appl. No. 18/674,613.
Application 18/674,613 is a continuation of application No. 17/349,299, filed on Jun. 16, 2021.
Application 17/349,299 is a continuation of application No. 15/795,062, filed on Oct. 26, 2017, granted, now 11,259,869.
Application 15/795,062 is a continuation of application No. 15/341,512, filed on Nov. 2, 2016, abandoned.
Application 15/341,512 is a continuation of application No. PCT/US2015/029734, filed on May 7, 2015.
Claims priority of provisional application 61/996,390, filed on May 7, 2014.
Prior Publication US 2024/0307117 A1, Sep. 19, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 18/14 (2006.01); A61B 5/0538 (2021.01); A61N 1/32 (2006.01); A61N 7/02 (2006.01); A61B 17/00 (2006.01); A61B 18/00 (2006.01); A61B 18/12 (2006.01); A61B 18/18 (2006.01); A61N 1/04 (2006.01)
CPC A61B 18/1492 (2013.01) [A61B 5/0538 (2013.01); A61N 1/327 (2013.01); A61N 7/022 (2013.01); A61B 2017/00026 (2013.01); A61B 2017/00154 (2013.01); A61B 2018/0022 (2013.01); A61B 2018/00267 (2013.01); A61B 2018/00351 (2013.01); A61B 2018/00404 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00654 (2013.01); A61B 2018/00827 (2013.01); A61B 2018/00839 (2013.01); A61B 2018/00875 (2013.01); A61B 2018/00892 (2013.01); A61B 2018/00994 (2013.01); A61B 2018/124 (2013.01); A61B 2018/1467 (2013.01); A61B 18/1815 (2013.01); A61B 2218/002 (2013.01); A61B 2576/023 (2013.01); A61N 1/0412 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method for conducting bipolar pulsed field ablation of cardiac tissue through a process of irreversible electroporation, the method comprising:
advancing a medical device comprising a catheter defining a proximal end and a distal end, the catheter comprising a plurality of electrodes disposed at the distal end;
connecting an electroporation system in electrical communication with the plurality of electrodes of the medical device via one or more leads extending within the catheter;
wherein the electroporation system comprises a generator;
generating, via the generator, at least one sequence of biphasic voltage pulses having at least one amplitude, the at least one amplitude between about 0.5 kV and about 10 kV;
applying, via the electroporation system, the at least one sequence of biphasic voltage pulses to the plurality of electrodes such that current associated with at least one first voltage pulse from the at least one sequence of voltage pulses flows between a first anode electrode and first and second cathode electrodes of the plurality of electrodes to thereby generate an electric field of sufficient strength to cause irreversible electroporation of the cardiac tissue proximate the distal end of the catheter;
applying, via the electroporation system, the at least one sequence of biphasic voltage pulses to the plurality of electrodes such that current associated with at least one second voltage pulse from the at least one sequence of biphasic voltage pulses flows between a second anode electrode and third and fourth cathode electrodes of the plurality of electrodes to thereby generate an electric field of sufficient strength to cause irreversible electroporation of the cardiac tissue proximate the distal end of the catheter, wherein the second anode electrode differs from the first anode electrode and wherein the third and fourth cathode electrodes differ from the first and second cathode electrodes.