US 12,408,851 B2
Canary on a chip: embedded sensors with bio-chemical interfaces
Axel Scherer, Barnard, VT (US); and Arti Gaur, Hanover, NH (US)
Assigned to CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US); and THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
Filed by CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US); and THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US)
Filed on Sep. 29, 2020, as Appl. No. 17/037,207.
Application 17/037,207 is a continuation of application No. 15/216,662, filed on Jul. 21, 2016, granted, now 10,820,844.
Claims priority of provisional application 62/204,825, filed on Aug. 13, 2015.
Claims priority of provisional application 62/195,895, filed on Jul. 23, 2015.
Prior Publication US 2021/0093233 A1, Apr. 1, 2021
Int. Cl. A61B 5/1473 (2006.01); A61B 5/00 (2006.01); A61B 5/07 (2006.01); A61B 5/145 (2006.01); A61B 5/1459 (2006.01); A61B 5/1486 (2006.01); A61B 17/34 (2006.01); A61M 5/142 (2006.01); A61M 5/172 (2006.01)
CPC A61B 5/1473 (2013.01) [A61B 5/0031 (2013.01); A61B 5/076 (2013.01); A61B 5/1451 (2013.01); A61B 5/14532 (2013.01); A61B 5/1459 (2013.01); A61B 5/14865 (2013.01); A61B 5/4839 (2013.01); A61B 17/3468 (2013.01); A61M 5/14276 (2013.01); A61M 5/172 (2013.01); A61M 5/1723 (2013.01); A61B 5/14546 (2013.01); A61B 5/14735 (2013.01); A61B 2560/0219 (2013.01); A61B 2562/0209 (2013.01); A61B 2562/028 (2013.01); A61B 2562/04 (2013.01); A61B 2562/125 (2013.01); A61M 2205/3523 (2013.01); A61M 2205/8237 (2013.01); A61M 2207/00 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A wireless body-implantable device comprising:
an electromagnetic wireless transmit system;
an electrochemical sensor monolithically integrated in an electronic chip fabricated on a silicon substrate, connected to the electromagnetic wireless transmit system, and comprising a functionalized layer comprising cell cultures or cell colonies confined within a semi-permeable cell containment barrier;
a hermetic package sealed to the silicon substrate, the hermetic package containing a payload and an electrolyte;
an actuator element integrated on the silicon substrate configured to heat the electrolyte thereby releasing the hermetic package from the silicon substrate triggering a release of the payload; and
electrodes in wells created by etched electrode metals on the electrochemical sensor and within the functionalized layer such that at least a portion of the functionalized layer is in the wells.