US 12,408,839 B2
Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data
Lihong Wang, Arcadia, CA (US); Liming Nie, St. Louis, MO (US); Xin Cai, St. Louis, MO (US); Konstantin Maslov, Pasadena, CA (US); Mark A. Anastasio, St. Louis, MO (US); Chao Huang, St. Louis, MO (US); and Robert W. Schoonover, St. Louis, MO (US)
Assigned to California Institute of Technology, Pasadena, CA (US)
Filed by California Institute of Technology, Pasadena, CA (US)
Filed on Apr. 22, 2021, as Appl. No. 17/302,041.
Application 17/302,041 is a continuation of application No. 14/436,581, granted, now 11,020,006, previously published as PCT/US2013/065594, filed on Oct. 18, 2013.
Claims priority of provisional application 61/762,415, filed on Feb. 8, 2013.
Claims priority of provisional application 61/715,671, filed on Oct. 18, 2012.
Prior Publication US 2021/0321874 A1, Oct. 21, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/055 (2006.01); A61B 6/03 (2006.01); A61B 6/50 (2024.01); A61M 31/00 (2006.01); G01N 29/24 (2006.01)
CPC A61B 5/0095 (2013.01) [A61B 5/0035 (2013.01); A61B 5/0042 (2013.01); A61B 5/055 (2013.01); A61B 5/4839 (2013.01); A61B 5/4848 (2013.01); A61B 5/725 (2013.01); A61B 5/7282 (2013.01); A61B 6/032 (2013.01); A61M 31/005 (2013.01); G01N 29/2418 (2013.01); A61B 6/501 (2013.01); A61B 2576/026 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method of photoacoustic imaging a brain within a skull of a subject, the method comprising:
obtaining an adjunct image dataset corresponding to the skull of the subject;
analyzing the adjunct image dataset to specify one or more parameters of a spatial model of one or more acoustic properties of the skull, wherein the one or more acoustic properties of the skull comprises a spatially-varying speed of sound associated with the skull;
obtaining one or more photoacoustic imaging signals corresponding to a region of the brain of the subject through the skull of the subject at a photoacoustic tomography (PAT) coordinate system;
registering the spatial model of the one or more acoustic properties of the skull of the subject to the PAT coordinate system to establish an imaging model; and
reconstructing a first photoacoustic image of the region of the brain from the one or more photoacoustic imaging signals by implementing an image reconstruction method, wherein the image reconstruction method is configured to utilize the one or more acoustic properties of the spatial model of the skull to mitigate aberrations of the one or more photoacoustic imaging signals induced by the skull of the subject by using the imaging model, wherein the image reconstruction method is configured to mitigate aberrations in part using the registration of the spatial model of the one or more acoustic properties of the skull to the PAT coordinate system.