US 12,079,960 B2
Systems, devices, and methods for harmonization of imaging datasets including biomarkers
Samuel Clark, New York, NY (US); Kenneth Wengler, New York, NY (US); and Guillermo Horga Hernandez, New York, NY (US)
Assigned to Terran Biosciences Inc., Miami Beach, FL (US); The Trustees of Columbia University in the City of New York, New York, NY (US); and The Research Foundation for Mental Hygiene, Inc., Menands, NY (US)
Filed by TERRAN BIOSCIENCES INC., New York, NY (US); THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US); and THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC., Menands, NY (US)
Filed on Mar. 11, 2022, as Appl. No. 17/693,166.
Claims priority of provisional application 63/159,915, filed on Mar. 11, 2021.
Prior Publication US 2022/0292657 A1, Sep. 15, 2022
Int. Cl. G06T 5/50 (2006.01); A61B 5/055 (2006.01); G06T 5/90 (2024.01); G06T 7/00 (2017.01); G16H 50/20 (2018.01)
CPC G06T 5/50 (2013.01) [A61B 5/055 (2013.01); G06T 5/90 (2024.01); G06T 7/0014 (2013.01); G16H 50/20 (2018.01); G06T 2207/10088 (2013.01); G06T 2207/20081 (2013.01); G06T 2207/30016 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method of harmonizing a neuromelanin dataset using a vendor specific combat coefficient, comprising:
measuring a first level of neuromelanin associated with a first dataset obtained using a set of MRI machines manufactured by a first vendor;
measuring a second level of neuromelanin associated with second dataset obtained using a reference MRI machine manufactured by a second vendor different from the first vendor;
implementing a machine learning (ComBat) algorithm to generate a vendor specific coefficient associated with the set of MRI machines, the vendor specific coefficient being based on at least one of (1) the first level of neuromelanin associated with a set of MRI machines or (2) the second level of neuromelanin associated with reference MRI machine;
obtaining a third dataset associated with a first MRI machine manufactured by the first vendor; and
applying the vendor specific coefficient directly on the third dataset from the first MRI machine manufactured by the first vendor to measure an adjusted third level of neuromelanin associated with first MRI machine compared to at least one of (1) the second level of neuromelanin associated with the reference MRI machine or (2) the second dataset.