US 12,078,628 B2
In vitro release testing (IVRT) device for orally inhaled drug products
Robert Price, Chepstow (GB); Arron Danson, Ross-on-Wye (GB); and Gregor Strnisa, Radece (SI)
Assigned to NANOPHARM LIMITED, Newport (GB)
Appl. No. 17/776,670
Filed by NANOPHARM LIMITED, Newport (GB)
PCT Filed Nov. 15, 2019, PCT No. PCT/EP2019/081551
§ 371(c)(1), (2) Date May 13, 2022,
PCT Pub. No. WO2021/093979, PCT Pub. Date May 20, 2021.
Prior Publication US 2022/0404326 A1, Dec. 22, 2022
Int. Cl. G01N 33/15 (2006.01); B01D 63/08 (2006.01); B01D 69/10 (2006.01)
CPC G01N 33/15 (2013.01) [B01D 63/087 (2013.01); B01D 69/10 (2013.01); B01D 2313/025 (2013.01); B01D 2325/0283 (2022.08)] 16 Claims
OG exemplary drawing
 
1. An in vitro release testing (IVRT) device for orally inhaled drug products, for use in an IVRT apparatus, said device comprising an air-permeable filter loaded with particulate material representing a dose of an orally inhaled drug product, said device comprising:
an upper filter support element and a lower filter support element, said loaded filter being circumferentially retained between said upper and lower support elements,
a filter cover to cover the upper surface of said loaded filter, and
a filter cover retainer provided to assemble and seal the IVRT device, said filter cover retainer having a spring to control the compressive load between said lower filter support element, said filter, said upper filter support element and said filter cover.