US 12,078,596 B2
Hand-held, massively-parallel, bio-optoelectronic instrument
Jonathan M. Rothberg, Guilford, CT (US); Benjamin Cipriany, Branford, CT (US); Todd Rearick, Cheshire, CT (US); Paul E. Glenn, Wellesley, MA (US); Faisal R. Ahmad, Guilford, CT (US); Todd Roswech, Westbrook, CT (US); Brittany Lathrop, Derby, CT (US); and Thomas Connolly, Cheshire, CT (US)
Assigned to Quantum-Si Incorporated, Branford, CT (US)
Filed by Quantum-Si Incorporated, Guilford, CT (US)
Filed on Jul. 24, 2018, as Appl. No. 16/043,651.
Claims priority of provisional application 62/536,330, filed on Jul. 24, 2017.
Prior Publication US 2019/0025214 A1, Jan. 24, 2019
Int. Cl. G01N 21/64 (2006.01); H01S 5/00 (2006.01); H01S 5/02253 (2021.01); H01S 5/024 (2006.01); H01S 5/026 (2006.01)
CPC G01N 21/6486 (2013.01) [G01N 21/6402 (2013.01); G01N 21/6408 (2013.01); G01N 21/6454 (2013.01); H01S 5/0071 (2013.01); H01S 5/02253 (2021.01); H01S 5/02461 (2013.01); H01S 5/0262 (2013.01); G01N 21/648 (2013.01); G01N 2021/6482 (2013.01); G01N 2201/0221 (2013.01); G01N 2201/0873 (2013.01)] 36 Claims
 
1. A bioanalytic instrument comprising:
a pulsed optical light source having a laser diode to produce a beam of optical pulses;
a chip receptacle adapted to receive a packaged bio-optoelectronic chip;
a beam-steering assembly adapted to steer the beam of optical pulses from the pulsed optical light source to the packaged bio-optoelectronic chip, the beam steering assembly including movable members;
an alignment structure physically supporting each of the pulsed optical light source, the chip receptacle, and beam steering assembly; and
a printed circuit board, registered to the alignment structure, on which the laser diode is mounted, and on which are also located a motion sensor which senses motion of the movable members in the beam-steering assembly;
wherein the motion sensor includes an inductive motion sensor that senses inductive changes of the moveable members.
 
36. A bioanalytic instrument comprising:
a optical light source;
a chip receptacle adapted to receive a packaged bio-optoelectronic chip;
a beam-steering assembly adapted to steer a beam of optical pulses from the pulsed optical light source to the packaged bio-optoelectronic chip, the beam steering assembly including movable members;
an alignment structure physically supporting each of the pulsed optical light source, the chip receptacle, and beam steering assembly; and
a driver, including a plurality of voice coils, configured to drive motion of the movable members in the beam steering assembly.