US 12,078,588 B2
Integrated multiplexed photometric module and method
Ramin Haghgooie, Arlington, AR (US); Kenneth T. Kotz, Auburndale, MA (US); Robert Granier, Boston, MA (US); and Anne Celia Petrofsky, Sudbury, MA (US)
Assigned to The General Hospital Corporation, Boston, MA (US)
Filed by The General Hospital Corporation, Boston, MA (US)
Filed on Apr. 19, 2023, as Appl. No. 18/303,073.
Application 16/216,397 is a division of application No. 15/677,459, filed on Aug. 15, 2017, granted, now 10,215,687, issued on Feb. 26, 2019.
Application 18/303,073 is a continuation of application No. 17/689,648, filed on Mar. 8, 2022, granted, now 11,644,409.
Application 17/689,648 is a continuation of application No. 16/918,501, filed on Jul. 1, 2020, granted, now 11,275,018, issued on Mar. 15, 2022.
Application 16/918,501 is a continuation of application No. 16/545,550, filed on Aug. 20, 2019, granted, now 10,739,250, issued on Aug. 11, 2020.
Application 16/545,550 is a continuation of application No. 16/216,397, filed on Dec. 11, 2018, granted, now 10,436,704, issued on Oct. 8, 2019.
Prior Publication US 2023/0251182 A1, Aug. 10, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 21/03 (2006.01); B01L 3/00 (2006.01); G01N 21/11 (2006.01); G01N 21/25 (2006.01)
CPC G01N 21/03 (2013.01) [B01L 3/5027 (2013.01); B01L 3/502723 (2013.01); G01N 21/11 (2013.01); G01N 21/253 (2013.01); B01L 2200/143 (2013.01); B01L 2200/146 (2013.01); B01L 2300/0851 (2013.01); B01L 2300/0858 (2013.01); B01L 2300/0877 (2013.01); B01L 2400/0622 (2013.01); G01N 2021/0346 (2013.01); G01N 2021/0357 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A microfluidic device comprising:
a stack of substrates;
a first microfluidic channel having:
a first inlet portion and a first outlet portion at least one of which traverses two substrates of the stack of substrates, and
a first cuvette portion between the first inlet portion and the first outlet portion,
wherein the microfluidic device is configured to temporarily stop a flow of a first fluid sample, passing through the first cuvette, for a first duration of time that is sufficient
to immobilize said first fluid sample, and
to prevent a first displacement of said first fluid sample with respect to the first cuvette portion.