| CPC C12Q 1/6883 (2013.01) [C12Q 1/6806 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/172 (2013.01)] | 5 Claims |
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1. A method for treating a human patient for post-operative pain, the method comprising the steps of
a) obtaining a biological sample from a patient in need of treatment for post-operative pain, wherein the biological sample is obtained prior to administering an opioid analgesic to the patient,
b) genotyping the biological sample from the patient to determine the patient's haplotype at four single nucleotide polymorphisms (SNPs) of the organic cation transporter 1 (OCT1) gene identified by rs12208357, rs34130495, rs72552763, and rs34059508, wherein the genotyping is performed using one or more of a PCR-based technique for nucleic acid amplification from the sample, gel electrophoresis, mass spectrometry, and microarray hybridization,
c) assigning an OCT1 haplotype of *1, *2, *3, *4, or *5 based on the patient's genotype at each of the four SNPs as follows
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assigning the patient to Group 0, 1, or 2 based on the patient's haplotype as follows:
Group 0: *1/*1
Group 1: *1/*2, *1/*3, *1/*4, or *1/*5
Group 2: *2/*2, *2/*3, *2/*4, *2/*5, *3/*3, *3/*4, *3/*5, *4/*4, *4/*5, or *5/*5, and
d) administering fentanyl, hydromorphone, codeine, oxycodone, hydrocodone, tramadol, ondansetron, dexamethasone, methadone, alfentanil, remifentanil, acetaminophen, a non-steroidal anti-inflammatory drug (NSAID), dexmedetomidine, or clonidine, to the patient assigned to Group 2 in step c), or
e) administering morphine to the patient assigned to Group 0 or 1 in step c).
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