	US 12,077,819 B2
	Compositions and processes for improved mass spectrometry analysis
Thomas Becker, La Jolla, CA (US)
Assigned to AGENA BIOSCIENCE, INC., San Diego, CA (US)
Filed by Agena Bioscience, Inc., San Diego, CA (US)
Filed on May 6, 2019, as Appl. No. 16/404,582.
Application 16/404,582 is a continuation of application No. 15/840,432, filed on Dec. 13, 2017, granted, now 10,329,612.
Application 15/840,432 is a continuation of application No. 15/065,739, filed on Mar. 9, 2016, granted, now 9,873,912, issued on Jan. 23, 2018.
Application 15/065,739 is a continuation of application No. 12/986,975, filed on Jan. 7, 2011, granted, now 9,310,378, issued on Apr. 12, 2016.
Application 12/986,975 is a continuation of application No. 12/014,671, filed on Jan. 15, 2008, granted, now 7,888,127, issued on Feb. 15, 2011.
Prior Publication US 2020/0224265 A1, Jul. 16, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C12Q 1/6872 (2018.01); G01N 33/68 (2006.01)

CPC C12Q 1/6872 (2013.01) [G01N 33/6848 (2013.01); G01N 33/6851 (2013.01); Y10T 436/143333 (2015.01); Y10T 436/24 (2015.01); Y10T 436/25125 (2015.01)]

21 Claims

1. A substrate for mass spectrometry, comprising target sites, wherein more than one of the target sites comprise a matrix material suitable for matrix-assisted laser desorption/ionization mass spectrometry and an adduct-reducing additive comprising ascorbic acid, or a salt, tautomer or analog thereof, wherein the molar ratio of the adduct-reducing additive to the matrix material is about 1:20, about 1:19, about 1:18, about 1:17, about 1:16, about 1:15, about 1:14, about 1:13 or about 1:12.