US 12,077,758 B2
Oligonucleotides for SARS-CoV-2 modulation
Anastasia Khvorova, Westborough, MA (US); Jonathan Watts, Worcester, MA (US); Zachary Kennedy, Worcester, MA (US); Annabelle Biscans, Cambridge, MA (US); Bruno Miguel da Cruz Godinho, Worcester, MA (US); Chantal Ferguson, Worcester, MA (US); Dimas Echeverria Moreno, Worcester, MA (US); Ken Yamada, Boston, MA (US); Daniel O′Reilly, Boston, MA (US); Kathryn Monopoli, Boston, MA (US); Vignesh Narayan Hariharan, Boston, MA (US); Qi Tang, Boston, MA (US); Sarah Davis, Boston, MA (US); Samuel Hildebrand, Boston, MA (US); Socheata Ly, Boston, MA (US); Minwook Shin, Boston, MA (US); Pranathi Meda Krishnamurthy, Boston, MA (US); Nicholas McHugh, Boston, MA (US); Jacquelyn Sousa, Boston, MA (US); Jillian Caiazzi, Boston, MA (US); Yann Thillier, Boston, MA (US); and Gitali Devi, Boston, MA (US)
Assigned to UNIVERSITY OF MASSACHUSETTS, Boston, MA (US)
Filed by UNIVERSITY OF MASSACHUSETTS, Boston, MA (US)
Filed on May 28, 2021, as Appl. No. 17/333,839.
Claims priority of provisional application 63/084,817, filed on Sep. 29, 2020.
Claims priority of provisional application 63/031,222, filed on May 28, 2020.
Prior Publication US 2023/0021431 A1, Jan. 26, 2023
Int. Cl. C12N 15/11 (2006.01); C12N 15/113 (2010.01)
CPC C12N 15/1131 (2013.01) [C12N 15/1136 (2013.01); C12N 15/1137 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/32 (2013.01)] 18 Claims
 
1. A double-stranded RNA oligonucleotide compound complementary to a SARS-CoV-2 nucleic acid sequence of SEQ ID NO:1,
the compound comprising a sense strand and an antisense strand, the antisense strand consisting of a sequence selected from the group consisting of SEQ ID NO: 2575, SEQ ID NO: 2577, SEQ ID NO: 2579, and SEQ ID NO: 2581.