	US 12,077,645 B2
	Alginate microcapsules for cell encapsulation and, manufacturing method therefor
Dong Yun Lee, Seoul (KR); Jae Bin Lee, Incheon (KR); Ki Myung Choi, Sejong-si (KR); Joo Hyun Shim, Chungcheongbuk-do (KR); and Jae Kyung Park, Chungcheongbuk-do (KR)
Assigned to OPTIPHARM CO., LTD, Chungcheongbuk-do (KR)
Appl. No. 17/042,345
Filed by OPTIPHARM CO., LTD, Chungcheongbuk-do (KR)
PCT Filed Apr. 2, 2019, PCT No. PCT/KR2019/003885 § 371(c)(1), (2) Date Sep. 28, 2020, PCT Pub. No. WO2019/194543, PCT Pub. Date Oct. 10, 2019.
Claims priority of application No. 10-2018-0038205 (KR), filed on Apr. 2, 2018.
Prior Publication US 2021/0017348 A1, Jan. 21, 2021
Int. Cl. C08J 7/04 (2020.01); A61K 9/50 (2006.01); A61K 31/353 (2006.01); A61K 35/39 (2015.01)

CPC C08J 7/04 (2013.01) [A61K 9/50 (2013.01); A61K 31/353 (2013.01); A61K 35/39 (2013.01); C08J 2305/04 (2013.01)]

5 Claims

1. A surface-modified alginate micro-capsule comprising a core-shell structure in which the core is fluidizable phase alginate, and the shell is an alginate hydrogel crosslinked with epigallocatechin gallate dimers, wherein the shell further includes an alginate coating layer, wherein the alginate coating layer has an amide bond with the epigallocatechin gallate dimer of the shell.