| CPC C07K 7/06 (2013.01) [A61K 38/08 (2013.01); A61K 47/6811 (2017.08); A61K 47/6855 (2017.08); A61K 47/6889 (2017.08); A61P 35/00 (2018.01); C07K 16/32 (2013.01); A61K 38/00 (2013.01); C07K 16/00 (2013.01); C07K 2319/00 (2013.01)] | 41 Claims |
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1. A compound of Formula (III):
 or a salt thereof, wherein
R1, R2, R3, R8a, R8b, R9, R10, R11, R12, R13, and R14 are each independently H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted cycloalkenyl;
R4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocyclyl;
R5 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, halo, or perhaloalkyl;
R6 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, halo, or perhaloalkyl;
R7 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocyclyl;
R15 is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted alkyl;
n is 0, 1, or 2;
X1 is —N(Rd)— or —O—;
X2 is O or S;
Y1 and Y2 are each independently —N(Rd)—, —O—, or —S—;
Y3 is —N(R4)—, —O—, —S—, or substituted or unsubstituted heterocycloalkyl;
Y4ª is —O—, —NRb—, or —S—;
each Rb and Rd is independently H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted cycloalkenyl;
W is (CH2)m—Z—(CH2)p;
Z is substituted or unsubstituted alkyl, substituted or unsubstituted substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or (CH2CH2O)q;
m, and p are each independently an integer from 0-12;
q is an integer from 1-12;
a, b, c, and d are each independently 0, 1, or 2;
each L1 is independently
 wherein a1 is 0, 1, or 2, and each Rx is unsubstituted or substituted alkyl;
each L2 is independently
 wherein b1 is an integer from 0 to 12;
each L3 is independently
 wherein each AA is an amino acid, c1 is an integer from 0-12, and c2 is an integer from 0-10;
each L4 is independently
 wherein d1 is an integer from 0-12, and d2 is an integer from 0-30; and
Fn is selected from the group consisting of
H, unsubstituted or substituted alkyl,
  wherein e1, e2, and e3 are each independently an integer from 0-12, and Re is H or alkyl.
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