US 12,077,582 B2
Antibodies to L-type voltage gated channels and related methods
Wilfred Arthur Jefferies, Surrey (CA); Kyung Bok Choi, Surrey (CA); Shawna Rose Stanwood, Burnaby (CA); Franz Fenninger, Vancouver (CA); Brett Alexander Eyford, Vancouver (CA); Lonna Munro, Vancouver (CA); Cheryl Gurine Pfeifer, Vancouver (CA); and Reinhard Gabathuler, Quebec (CA)
Assigned to The University of British Columbia, Vancouver (CA)
Filed by The University of British Columbia, Vancouver (CA)
Filed on Sep. 16, 2022, as Appl. No. 17/946,921.
Application 17/946,921 is a continuation of application No. 16/751,951, filed on Jan. 24, 2020, granted, now 11,492,400.
Application 16/751,951 is a continuation of application No. 15/549,912, abandoned, previously published as PCT/US2016/018114, filed on Feb. 16, 2016.
Claims priority of provisional application 62/280,557, filed on Jan. 19, 2016.
Claims priority of provisional application 62/115,823, filed on Feb. 13, 2015.
Prior Publication US 2023/0203154 A1, Jun. 29, 2023
Int. Cl. C07K 16/28 (2006.01); C07K 14/705 (2006.01); C07K 16/30 (2006.01)
CPC C07K 16/28 (2013.01) [C07K 14/705 (2013.01); C07K 16/30 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01)] 1 Claim
 
1. An isolated antibody, or antigen-binding fragment thereof, which binds to an alpha I subunit of an L-type voltage-gated calcium channel, wherein the antibody or antigen-binding fragment thereof, specifically binds to an amino acid sequence of an extracellular domain selected from SEQ ID NO:2 and which comprises:
a heavy chain variable region (VH) having the VH sequence of SEQ ID NO:37; and a light chain variable region (VL) having the VL sequence of SEQ ID NO:41, wherein (i) VH comprises VHCDR1 and VHCDR2 amino acid sequences of SEQ ID NOS:38-39; and (ii) VL comprises VLCDR1, VLCDR2 and VLCDR3 amino acid sequences of SEQ ID NO: 42, LAS, and SEQ ID NO: 44.