	US 12,077,572 B2
	Monoclonal antibody for spike protein of middle east respiratory syndrome coronavirus, and use thereof
Hansaem Lee, Chungcheongbuk-do (KR); Janghoon Choi, Chungcheongbuk-do (KR); Sungsoon Kim, Chungcheongbuk-do (KR); Lingshu Wang, Bethesda, MD (US); Barney Graham, Bethesda, MD (US); and John R Mascola, Bethesda, MD (US)
Assigned to THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, Bethesda, MD (US); and KOREA (CENTER FOR DISEASE CONTROL AND PREVENTION), Chungcheongbuk-do (KR)
Filed by The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US); and Korea (Center for Disease Control and Prevention), Chungcheongbuk-do (KR)
Filed on Sep. 25, 2022, as Appl. No. 17/952,308.
Application 17/952,308 is a division of application No. 16/641,580, abandoned, previously published as PCT/KR2018/009754, filed on Aug. 23, 2018.
Claims priority of application No. 10-2017-0106836 (KR), filed on Aug. 23, 2017.
Prior Publication US 2023/0265169 A1, Aug. 24, 2023
Int. Cl. C07K 16/10 (2006.01); G01N 33/569 (2006.01)

CPC C07K 16/10 (2013.01) [G01N 33/56983 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); G01N 2333/165 (2013.01)]

9 Claims

1. A method for treating Middle East Respiratory Syndrome (MERS) in a subject, said method comprising:

administering to the subject an effective amount of a monoclonal antibody, the monoclonal antibody having binding specificity to Middle East Respiratory Syndrome coronavirus (MERS-CoV) spike protein, the monoclonal antibody comprising:

human immunoglobulin heavy chain constant region and human immunoglobulin light chain constant region, and

a combination of heavy chain variable region (VH) and light chain variable region (VL) selected from the group consisting of:

VH according to SEQ ID NOs: 1 and VL according to SEQ ID NOs 2;

VH according to SEQ ID NOs: 3 and VL according to SEQ ID NOs 4;

VH according to SEQ ID NOs: 9 and VL according to SEQ ID NOs 10;

VH according to SEQ ID NOs: 11 and VL according to SEQ ID NOs 12;

VH according to SEQ ID NOs: 19 and VL according to SEQ ID NOs 20; and

VH according to SEQ ID NOs: 21 and VL according to SEQ ID NOs 22.