US 12,077,569 B2
Multi subunit protein modules, cells expressing same and uses thereof
Yaron Carmi, Tel Aviv (IL); Peleg Rider, Tel Aviv (IL); Diana Rasoulouniriana, Tel Aviv (IL); and Lior Tal, Tel Aviv (IL)
Assigned to Ramot at Tel-Aviv University Ltd., Tel-Aviv (IL)
Filed by Ramot at Tel-Aviv University Ltd., Tel-Aviv (IL)
Filed on Dec. 21, 2022, as Appl. No. 18/085,632.
Application 18/085,632 is a continuation in part of application No. PCT/IL2021/050763, filed on Jun. 22, 2021.
Claims priority of provisional application 63/042,080, filed on Jun. 22, 2020.
Prior Publication US 2023/0340070 A1, Oct. 26, 2023
Int. Cl. C07K 14/735 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 37/04 (2006.01); C07K 16/32 (2006.01); C12N 5/0783 (2010.01)
CPC C07K 14/70535 (2013.01) [A61P 37/04 (2018.01); C12N 5/0636 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01)] 26 Claims
 
1. A recombinant multi subunit protein module comprising at least three recombinant cell membrane polypeptides each comprising an amino acid sequence of an Fc receptor common γ chain (FcRγ), wherein said amino acid sequence is capable of transmitting an activating signal; wherein at least one but not all of said at least three recombinant polypeptides comprises an extracellular binding domain capable of binding a target that is presented on a cell surface of a target cell of an immune cell, such that upon binding of said extracellular binding domain to said target said activating signal is transmitted in an immune cell expressing said multi subunit protein module.