US 12,077,522 B2
Heterocyclic compound and application thereof
Tatsuhiko Fujimoto, Kanagawa (JP); Koichiro Fukuda, Kanagawa (JP); Hiromichi Sugimoto, Kanagawa (JP); Kentaro Rikimaru, Kanagawa (JP); Yoshihiro Banno, Kanagawa (JP); Takahiro Matsumoto, Kanagawa (JP); Norihito Tokunaga, Kanagawa (JP); Yoshihide Tomata, Kanagawa (JP); Yuji Ishichi, Kanagawa (JP); Shogo Marui, Kanagawa (JP); Tsuneo Oda, Kanagawa (JP); Tohru Miyazaki, Kanagawa (JP); Yasutaka Hoashi, Kanagawa (JP); Yasushi Hattori, Kanagawa (JP); Yuichi Kajita, Kanagawa (JP); Yuhei Miyanohana, Kanagawa (JP); and Tatsuki Koike, Kanagawa (JP)
Assigned to Takeda Pharmaceutical Company Limited, Osaka (JP)
Appl. No. 17/256,330
Filed by Takeda Pharmaceutical Company Limited, Osaka (JP)
PCT Filed Jun. 27, 2019, PCT No. PCT/JP2019/025554
§ 371(c)(1), (2) Date Dec. 28, 2020,
PCT Pub. No. WO2020/004536, PCT Pub. Date Jan. 2, 2020.
Claims priority of application No. 2018-125332 (JP), filed on Jun. 29, 2018.
Prior Publication US 2021/0269420 A1, Sep. 2, 2021
Int. Cl. C07D 401/14 (2006.01); C07D 211/56 (2006.01); C07D 405/14 (2006.01)
CPC C07D 401/14 (2013.01) [C07D 211/56 (2013.01); C07D 405/14 (2013.01)] 11 Claims
 
1. A compound represented by the formula (I):

OG Complex Work Unit Chemistry
wherein
R1 is
(1) a mono- or di-C1-6 alkyl-carbamoyl group, or
(2) a 3- to 6-membered monocyclic non-aromatic heterocyclic group;
R2 is
(1) a C1-6 alkyl-carbonyl group,
(2) a C3-10 cycloalkyl-carbonyl group optionally substituted by 1 to 3 hydroxy groups,
(3) a 3- to 14-membered non-aromatic heterocyclylcarbonyl group,
(4) a C1-6 alkoxy-carbonyl group, or
(5) a mono- or di-C1-6 alkyl-carbamoyl group;
L1 is an oxygen atom;
L2 is a methylene group;
Ring A is
(1) a pyrrolidine ring having no additional substituent, or
(2) a piperidine ring having no additional substituent;
Ring B is
(1) a cyclohexane ring having no additional substituent, or
(2) a 6-membered monocyclic saturated heterocycle having no additional substituent; and
Ring C is
(1) a 6-membered monocyclic aromatic heterocycle optionally further substituted by 1 to 3 halogen atoms, or
(2) a benzene ring optionally further substituted by 1 to 3 halogen atoms, or a salt thereof.