US 12,077,509 B2
Compounds and methods for the targeted degradation of androgen receptor
Hanqing Dong, Madison, CT (US); Keith R. Hornberger, Southbury, CT (US); and Lawrence B. Snyder, Killingworth, CT (US)
Assigned to Arvinas Operations, Inc., New Haven, CT (US)
Filed by Arvinas Operations, Inc., New Haven, CT (US)
Filed on Jun. 22, 2023, as Appl. No. 18/213,055.
Application 16/577,901 is a division of application No. 15/730,728, filed on Oct. 11, 2017, granted, now 10,584,101, issued on Mar. 10, 2020.
Application 18/213,055 is a continuation of application No. 17/539,679, filed on Dec. 1, 2021, granted, now 11,952,347.
Application 17/539,679 is a continuation of application No. 16/938,864, filed on Jul. 24, 2020, granted, now 11,236,051, issued on Feb. 1, 2022.
Application 16/938,864 is a continuation of application No. 16/577,901, filed on Sep. 20, 2019, granted, now 10,844,021, issued on Nov. 24, 2020.
Claims priority of provisional application 62/528,385, filed on Jul. 3, 2017.
Claims priority of provisional application 62/406,888, filed on Oct. 11, 2016.
Prior Publication US 2023/0331681 A1, Oct. 19, 2023
Int. Cl. A61K 31/166 (2006.01); A61K 31/02 (2006.01); A61K 31/277 (2006.01); A61K 31/496 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01); C07D 205/04 (2006.01); C07D 209/48 (2006.01); C07D 211/76 (2006.01); C07D 213/72 (2006.01); C07D 221/20 (2006.01); C07D 231/12 (2006.01); C07D 233/42 (2006.01); C07D 237/08 (2006.01); C07D 239/24 (2006.01); C07D 241/04 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01)
CPC C07D 233/42 (2013.01) [A61K 31/02 (2013.01); A61K 31/166 (2013.01); A61K 31/277 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); C07D 205/04 (2013.01); C07D 209/48 (2013.01); C07D 211/76 (2013.01); C07D 213/72 (2013.01); C07D 221/20 (2013.01); C07D 231/12 (2013.01); C07D 237/08 (2013.01); C07D 239/24 (2013.01); C07D 241/04 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01)] 4 Claims
 
1. A compound, wherein the compound is:

OG Complex Work Unit Chemistry